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Products

LTC

LTC

LTC is an interactive package for physical mapping of fingerprinted BAC libraries.

LTC can be used for construction, verification, elongation, merging, and “curing” of contigs and MTPs.

Features:

  • More effective detection of problematic clones and clone overlaps in comparison to standard FPC software (based on exploring of parallel clone overlaps)
  • Possibility to detect false contigs by checking the topological structure of clone overlaps
  • Construction of reliable and longer contigs compared to FPC
  • Reviewing, editing, repairing and elongation of contigs constructed with FPC
  • MTP selection with taking into account clone overlaps (hence reducing the risk of gaps)
  • Possibility to automatically reselect MTP with maximal using of already selected MTP clones with especial preference for some clones (e.g., already sequenced)
  • Ordering of long sequence contigs of individual clones or pools of overlapping clones
  • Mapping of long sequence contigs (>15kbp) to clones based on in silico fingerprinting
  • Mapping of fingerprinted BACs/physical maps to long and very long sequence contigs
  • Interactive editing of contigs and MTP facilitated by graphical visualization
  • User-friendly interface for contig elongation and merging
  • More powerful detection of putatively problematic clones
  • Tools for repairing of gaps observed in the MTP
  • Possibility to work with large BAC libraries (e.g., 106 clones)
  • Taking into account different versions of fingerprinting
  • Taking into account clone sequence for contig and MTP editing
  • Tools assisting in the identification of positive clones from the set of positive 3D-pools