Products
LTCLTC
LTC is an interactive package for physical mapping of fingerprinted BAC libraries.
LTC can be used for construction, verification, elongation, merging, and “curing” of contigs and MTPs.
Features:
- More effective detection of problematic clones and clone overlaps in comparison to standard FPC software (based on exploring of parallel clone overlaps)
- Possibility to detect false contigs by checking the topological structure of clone overlaps
- Construction of reliable and longer contigs compared to FPC
- Reviewing, editing, repairing and elongation of contigs constructed with FPC
- MTP selection with taking into account clone overlaps (hence reducing the risk of gaps)
- Possibility to automatically reselect MTP with maximal using of already selected MTP clones with especial preference for some clones (e.g., already sequenced)
- Ordering of long sequence contigs of individual clones or pools of overlapping clones
- Mapping of long sequence contigs (>15kbp) to clones based on in silico fingerprinting
- Mapping of fingerprinted BACs/physical maps to long and very long sequence contigs
- Interactive editing of contigs and MTP facilitated by graphical visualization
- User-friendly interface for contig elongation and merging
- More powerful detection of putatively problematic clones
- Tools for repairing of gaps observed in the MTP
- Possibility to work with large BAC libraries (e.g., 106 clones)
- Taking into account different versions of fingerprinting
- Taking into account clone sequence for contig and MTP editing
- Tools assisting in the identification of positive clones from the set of positive 3D-pools







